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Ausgewählte Publikationen aus den Jahren zwischen 1984 und 2023

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Baumann, L., Braunbeck, T. (2023) European Commission, Directorate-General for Environment, Development of a study protocol for regulatory testing to identify endocrine disrupting substances in biotic systems, Publications Office of the European Union, 2023, https://data.europa.eu/doi/ 10.2779/396460.

Frese, L. and Braunbeck, T. (2023) Adapting classic paradigms to analyze alterations of shoal-wide behavior in early-life stages of zebrafish (Danio rerio) − A case study with fluoxetine. Neurotoxicol. Teratol. 95: 107136.

Kämmer, N. and Braunbeck, T. (2023) A novel automated method for the simultaneous detection of breathing frequency and amplitude in zebrafish (Danio rerio) embryos and larvae. Aquat. Toxicol. 258: 106493.

Brotzmann, K., Escher, S.E., Walker, P. and Braunbeck, T. (2022) Potential of the zebrafish (Danio rerio) embryo test to discriminate between chemicals of similar molecular structure — a study with valproic acid and 14 of its analogues. Arch. Toxicol. DOI: https://doi.org/10.1007/s00204-022-03340-z

Escher, S.E., Aguayo-Orozco, A., Benfenati, E., Bitsch, A., Braunbeck, T., Brotzmann, K., Bois, F., van der Burg, B., Castel, J., Exner, T.E., Gadaleta, D., GArnder, I., Goldmann, D., Hatley, O., Golbamaki, N., Graepel, R., Jennings, P., Limonciel, A., Long, A., Maclennan, R., Mombelli, E., Norinder, U., Jain, S., Santos CApi8nha, L., Taboureau, O.T., Tolosa, L., Vrijenhoek, N.G., van Vugt-Lussenburg, B.M.A., Walker, P., van de Water, B., Wehr, M., White, A., Zdrazil, B. and Fisher, C. (2022) Integrate mechanistic evidence from new approach methodologies (NAMs) into a read-across assessment to characterise trends in shared mode of action. Toxicol. in Vitro 79: 105269.

Gölz, L., Baumann, L., Pannetier, P., Braunbeck, T., Knapen, D. and Vergauwen, L. (2022) AOP report: Thyroperoxidase inhibition leading to altered visual function in fish via altered retinal layer structure. Environ. Toxicol. Chem. 41: 2632-2648.

Hanslik, L., Huppertsberg, S., Kämmer, N., Knepper, T.P. and Braunbeck, T. (2022) Rethinking the relevance of microplastics as vector for anthropogenic contaminants: Adsorption of toxicants to microplastics during exposure in a highly polluted stream - Analytical quantification and assessment of toxic effects in zebrafish (Danio rerio). Sci. Total Environ. 816: 151640.

Hanslik, L., Seiwert, B., Huppertsberg, S., Knepper, T.P., Reemtsma, T. and Braunbeck, T. (2022) Biomarker responses in zebrafish (Danio rerio) following long-term exposure to microplastic-associated chlorpyrifos and benzo(k)fluoranthene. Aquat. Toxicol. 245: 106120.

Kämmer, N., Erdinger, L. and Braunbeck, T. (2022) The onset of active gill respiration in post-embryonic zebrafish (Danio rerio) larvae triggers an increased sensitivity to neurotoxic compounds. Aquat. Toxicol. 249: 106240.

Kraft, M., Gölz, L., Rinderknecht, M., Koegst, J., Braunbeck, T. and Baumann, L. (2022) Developmental exposure to triclosan and benzophenone-2 causes morphological alterations in zebrafish (Danio rerio) thyroid follicles and eyes. Environ. Sci. Pollut. Res. Int. 1-14.

von Hellfeld, R., Pannetier, P. and Braunbeck, T. (2022) Specificity of time- and dose-dependent morphological endpoints in the fish embryo acute toxicity (FET) test for substances with diverse modes of action: the search for a "fingerprint". Environ Sci Pollut Res Int 29: 16176-16192.

von Hellfeld, R., Ovcharova, V., Bevan, S., Lazaridi, M.-A., Bauch, C., Walker, P., Hougaard Bennekou, S., Forsby, A. and Braunbeck, T. (2022) Zebrafish embryo neonicotinoid developmental neurotoxicity in the FET test and behavioral assays. ALTEX 39: 367-387.

von Hellfeld, R., Pannetier, P. and Braunbeck, T. (2022) Specificity of time- and dose-dependent morphological endpoints in the fish embryo acute toxicity (FET) test for substances with diverse modes of action: the search for a "fingerprint". Environ. Sci. Pollut. Res. Int. 29: 16176-16192.

Wlodkowic, D., Bownik, A., Leitner, C., Stengel, D. and Braunbeck, T. (2022) Beyond the behavioural phenotype: Uncovering mechanistic foundations in aquatic eco-neurotoxicology. Sci. Total Environ. 829:

Brotzmann, K., Wolterbeek, A., Kroese, D. and Braunbeck, T., 2021. Neurotoxic effects in zebrafish embryos by valproic acid and nine of its analogues: the fish‑mouse connection? Arch. Toxicol. 95: 641–657.

Loerracher, A.-K., Braunbeck, T., 2021. Cytochrome P450‑dependent biotransformation capacities in embryonic, juvenile and adult stages of zebrafish (Danio rerio) − a state‑of‑the‑art review. Arch. Toxicol. Arch. Toxicol. 95: 2299-2334.

Monteiro Teixeira, T.M., Arraes, I.G., Abreu, D.C., Oliveira, K.M., Correa, R.S., Batista, A.A., Braunbeck, T. and de Paula Silveira Lacerda, E. (2021) Ruthenium complexes show promise when submitted to toxicological safety tests using alternative methodologies. Eur. J. Med. Chem. 216:113262

Simeon, S., Beaudouin, R., Brotzmann, K., Braunbeck, T. and Bois, F.Y., (2021) Multistate models of developmental toxicity: Application to valproic acid-induced malformations in the zebrafish embryo. Toxicol. Appl. Pharmacol. 414: 115424.

Batel, A., Baumann, L., Carteny, C.C., Cormier, B., Keiter, S.H., Braunbeck, T., 2020. Histological, enzymatic and chemical analyses of the potential effects of differently sized microplastic particles upon long-term ingestion in zebrafish (Danio rerio). Mar. Pollut. Bull. April 2020, 111022 doi: 10.1016/j.marpolbul.2020.111022 153:111022.

Braunbeck, T., Böhler, S., Knörr, S., Lörracher, A.-K., Pelka, K.E., Kais, B., 2020. Development of an OECD Guidance Document for the Application of OECD Test Guideline 236 (Acute Fish Embryo Toxicity Test). UBA Texte 94/2020. ISSN 1862-4804, 106 pp.

Baumann, L., Holbech, H., Schmidt-Posthaus, H., Moissl, A.P., Hennies, M., Tiedemann, J., Weltje, L., Segner, H., Braunbeck, T., 2020. Does hepatotoxicity interfere with endocrine activity in zebrafish (Danio rerio)? Chemosphere 238. DOI 10.1016/j.chemosphere.2019.124589

Braunbeck, T., Erdinger, L., Frimmel, F.H., Hollert, H., Knasmüller, S., DeMarini, D.M., Plewa, M.J., Richardson, S.D., Triebskorn, R., de Aragão Umbuzeiro, G., White, P.A., 2020. Obituary for Tamara Grummt. Environ. Sci. Eur. 32:66.

Brotzmann, K., Wolterbeek, A., Kroese, D., Braunbeck, T., 2020. Neurotoxic effects in zebrafish embryos by valproic acid and nine of its analogues: the fish mouse connection? Arch. Toxicol. https://doi.org/10.1007/s00204-020-02928-7.

Cousin, X., Batel, A., Bringer, A., Hess, S., BÃgout, M.-L., Braunbeck, T., 2020. Microplastics and sorbed contaminants & trophic exposure in fish sensitive early life stages. Mar. Environ. Res. 161. 105126. https://doi.org/10.1016/j.marenvres.2020.105126.

Grummt, T., Braunbeck, T., Hollert, H., Kramer, M., 2020. RiSKWa Guideline: Hazard-based risk management of anthropogenic trace substances in drinking water to secure a long-term drinking water supply. Federal Ministry of Education and Research (BMBF), Funding code: 02WRS1282.

Hanslik, L., Sommer, C., Huppertsberg, S., Dittmar, S., Knepper, T.P., Braunbeck, T., 2020. Microplastic-associated trophic transfer of benzo(k)fluoranthene in a limnic food web: Effects in two freshwater invertebrates (Daphnia magna, Chironomus riparius) and zebrafish (Danio rerio). Comp. Biochem. Physiol. 237 C:108849.

Heinrich, P., Braunbeck, T. (2020) Microplastic particles reduce EROD-induction specifically by highly lipophilic compounds in RTL-W1 cells. Ecotox. Environ. Safety 189, 110041.

Heinrich, P., Hanslik, L., Kämmer, N., Braunbeck, T., 2020. The tox is in the detail: technical fundamentals for designing, performing, and interpreting experiments on toxicity of microplastics and associated substances. Environ. Sci. Pollut. Res. 27, 22292-22318.

Jekel, M., Anger, P., Bannick, C.G., Barthel, A.-K., Braun, U., Braunbeck, T., Dittmar, S., Eisentraut, P., Elsner, M., Gnir, R., Grummt, T., Hanslik, L., Huppertsberg, S., Ivleva, N.P., Klöckner, P., Knepper, T.P., Köhler, H.-R., Krais, S., Kuckelkorn, J., May, E., Müller, Y.K., NieÃÿner, R., Obermaier, N., Oehlmann, J., Pittroff, M., Reemtsma, T., Schmieg, H., Schmitt, T., Schür, C., Storck, F.R., Strobel, C., Triebskorn, R., Wagner, S., Wagner, M., Witzig, C.S., Zumbülte, N., Ruhl, A.S., 2020. Mikroplastik im Wasserkreislauf - Probennahme, Probenaufbereitung, Analytik, Vorkommen und Bewertung (MiWa). Universitätsverlag TU Berlin, https://depositonce.tu-berlin.de/handle/11303/11522

Knoll, S., Jacob, S., Mieck, S., Triebskorn, R., Braunbeck, T., Huhn, C., 2020. Development of a capillary electrophoresis–mass spectrometry method for the analysis of metformin and its transformation product guanylurea in biota. Anal . Bioanal. Chem. 412, 4985-4996.

Krebs, A., van Vugt-Lussenburg, B.M.A., Waldmann, T., Albrecht, W., Boei, J., Ter Braak, B., Brajnik, M., Braunbeck, T., Brecklinghaus, T., Busquet, F., Dinnyes, A., Dokler, J., Dolde, X., Exner, T.E., Fisher, C., Fluri, D., Forsby, A., Hengstler, J.G., Holzer, A.K., Janstova, Z., Jennings, P., Kisitu, J., Kobolak, J., Kumar, M., Limonciel, A., Lundqvist, J., Mihalik, B., Moritz, W., Pallocca, G., Ulloa, A.P.C., Pastor, M., Rovida, C., Sarkans, U., Schimming, J.P., Schmidt, B.Z., Stöber, R., Strassfeld, T., van de Water, B., Wilmes, A., van der Burg, B., Verfaillie, C.M., von Hellfeld, R., Vrieling, H., Vrijenhoek, N.G., Leist, M., 2020. The EU-ToxRisk method documentation, data processing and chemical testing pipeline for the regulatory use of new approach methods. Arch. Toxicol. 94, 2435-2461.

Kroese, D., Blum, J., Bois, F., Braunbeck, T., Brotzmann, K., Fisher, C., Jaklin, M., Kisitu, J., Koch, B., Kustermann, S., Leist, M., Lussenburg, B., Norinder, U., Simeon, S., van der Burg, B., van Vugt, B., Waldmann, T., Zdrazil, B. (2020a) Case study on the use of Integrated approaches to testing and assessment for read-across based filling of developmental toxicity data gap for methyl hexanoic acid. OECD Series on Testing and Assessment No. 325: ENV/JM/MONO(2020)21. Link: http://www.oecd.org/chemicalsafety/risk-assessment/iata-integrated-approaches-to-testing-and-assessment.htm

Kroese, D., Blum, J., Bois, F., Braunbeck, T., Brotzmann, K., Fisher, C., Jaklin, M., Kisitu, J., Koch, B., Kustermann, S., Leist, M., Lussenburg, B., Norinder, U., Simeon, S., van der Burg, B., van Vugt, B., Waldmann, T., Zdrazil, B. (2020b) Annex II: In vitro models - detailed description of methods and generated data within case study on the use of integrated approaches to testing and assessment for read-across based filling of developmental toxicity data gap for methyl hexanoic acid. OECD Series on Testing and Assessment No. 325: ENV/JM/MONO(2020)21/ANN2. Link: http://www.oecd.org/chemicalsafety/risk-assessment/iata-integrated-approaches-to-testing-and-assessment.htm

Kroese, D., Blum, J., Bois, F., Braunbeck, T., Brotzmann, K., Fisher, C., Jaklin, M., Kisitu, J., Koch, B., Kustermann, S., Leist, M., Lussenburg, B., Norinder, U., Simeon, S., van der Burg, B., van Vugt, B., Waldmann, T., Zdrazil, B. (2020c) Annex III: In silico models - detailed description of methods and generated data within case study on the use of integrated approaches to testing and assessment for read-across based filling of developmental toxicity data gap for methyl hexanoic acid. OECD Series on Testing and Assessment No. 325: ENV/JM/MONO(2020)21/ANN3. Link: http://www.oecd.org/chemicalsafety/risk-assessment/iata-integrated-approaches-to-testing-and-assessment.htm

Loerracher, A.-K., Braunbeck, T. (2020) In vivo fluorescence-based characterization of cytochrome P450 activity during embryonic development of zebrafish (Danio rerio). Ecotox. Environ. Safety 192, 110330.

Loerracher, A.K. and Braunbeck, T. (2020) Inducibility of cytochrome P450-mediated 7-methoxy-coumarin-O-demethylase activity in zebrafish (Danio rerio) embryos. Aquat Toxicol 225: 105540.

Paparella, M., Scholz, S., Belanger, S., Bicherel, P., Braunbeck, T., Connors, K., FaÃÿbender, C., Halder, M., Lillicrap, A., Liska, R., Schirmer, K., Stoddart, G., Thomas, P., Walter-Rohde, S., 2020. Limitations and uncertainties of acute fish toxicity assessments are reducible by alternatives. ALTEX doi:10.14573/altex.2006051.

Pauler, C.M., Isselstein, J., Suter, M., Berard, J., Braunbeck, T., Schneider, M.K., 2020. Choosy grazers: Influence of plant traits on forage selection by three cattle breeds. Funct. Ecol. 34, 980-992.

Pauler, C.M., Isselstein, J., Suter, M., Berard, J., Braunbeck, T., Schneider, M.K., 2020. Selektive graessere. Highland Nyt 2020-2, 13-22.

Regoli, F., Albentosa, M., Avio, C.G., Batel, A., Bebianno, M.J., Begout, M.-L., Beiras, R., Bellas, J., Blust, R., Bour, A., Braunbeck, T., Cachot, J., Carteny, C.C., Cormier, B., Cousin, X., Cuesta, A., Angeles Esteban, M., Faimali, M., Gambardella, C., Garaventa, F., Gorbi, S., Guilhermino, L., Hylland, K., Keiter, S., Kopke, K., Morin, B., Pacheco, A., Pittura, L., Town, R., Vieira, L.R. 2020. Insights on ecotoxicological effects of microplastics in marine ecosystems: the EPHEMARE project. In: Cocca, M., DiPace, E., Errico, M.E., Gentile, G., Montarsolo, A., Mossotti, R., Avella, M. (eds.) Proceedings of the 2nd International Conference on Microplastic Pollution in the Mediterranean Sea. Springer Water Series. DOI: 10.1007/978-3-030-45909-3_4.

Schaub, S., Braunbeck, T. (2020) Transition towards sustainable pharmacy? The influence of public debates on policy responses to pharmaceutical contaminants. Environ. Sci. Eur. 22:140.

Siméon, S., Brotzmann, K., Fisher, C., Gardner, I., Silvester, S., Maclennan, R., Walker, P., Braunbeck, T., Bois, F.Y., 2020. Development of a generic zebrafish embryo PBPK model and application to the developmental toxicity assessment of valproic acid analogs. Reprod. Toxocol. 93, 219-229.

Siméon, S., Brotzmann, K., Fisher, C., Gardner, I., Silvester, S., Maclennan, R., Walker, P., Braunbeck, T., Bois, F., 2020. Corrigendum to “Development of a generic zebraïsh embryo PBPK model and application to the developmental toxicity assessment of valproic acid analogs” [Reprod. Toxicol. 93 (2020) 219-229] Reprod. Toxicol. https://doi.org/10.1016/j.reprotox.2020.10.006.

von Hellfeld, R., Brotzmann, K., Baumann, L., Strecker, R., Braunbeck, T., 2020. Adverse effects in the fish embryo acute toxicity (FET) test: a catalogue of unspecific morphological changes versus more specific effects in zebrafish (Danio rerio) embryos. Environ. Sci. Eur. 32:122.

Zindler, F., Stoll, S., Baumann, L., Knoll, S., Huhn, C., Braunbeck, T., 2020. Do environmentally relevant concentrations of fluoxetine and citalopram impair stress-related behavior in zebrafish (Danio rerio) embryos? Chemosphere 261, December 2020, 127753.

Zindler, F., Tisler, S., Loerracher, A.K., Zwiener, C., Braunbeck, T., 2020. Norfluoxetine is the only metabolite of fluoxetine in zebrafish (Danio rerio) embryos that accumulates at environmentally relevant exposure scenarios. Environ. Sci. Technol. 54, 4200-4209.

Braunbeck, T., Geercken, J., Guhl, B., Klein, R., Löffler, H., Triebskorn, R., von der Trenck, T. 2019. Biological procedures to determine environmental impact (bioindication): passive biomonitoring with fishes as bioaccumulators – sampling procedures. VDI Guideline 4230, Part 4.

Cormier, B., Batel, A., Cachot, J., Bégout, M.-L., Braunbeck, T., Cousin, X., Keiter, S.H., 2019. Multi-laboratory hazard assessment of contaminated microplastic particles by means of enhanced fish embryo test with the zebrafish (Danio rerio). Front. Environ. Sci. 7:135, 121-134.

Du Plessis, B., Regnier, T., Combrinck, S., Heinrich, P., Braunbeck, T., 2019. Effect of pH on the toxicity of fumonisins towards the RTL-W1 cell line and zebrafish (Danio rerio) embryos. Toxicol. Lett. 313, 101-107.

Heinrich, P., Braunbeck, T. 2019a Microplastic testing in vitro: Realistic loading of pollutants, surfactant-free solid surface-dosing and bioanalytical detection using a sensitivity-optimized EROD assay. Toxicol. in vitro 54: 194-201.

Heinrich, P, Braunbeck, T. 2019b Bioavailability of microplastic-bound pollutants in vitro: The role of adsorbate lipophilicity and surfactants. Comp. Biochem. Physiol. 221C: 59-67.

Pauler, C.M., Isselstein, J., Braunbeck, T., Schneider, M.K., 2019. Influence of Highland and production-oriented cattle breeds on pasture vegetation: A pairwise assessment across broad environmental gradients. Agric. Ecosys. Environ. 284, 106585.

Tisler, S., Zindler, F., Freeling, F., Nödler, K., Toelgyesi, L., Braunbeck, T., Zwiener, C., 2019. Transformation products of fluoxetine formed by photodegradation in water and biodegradation in zebrafish embryos (Danio rerio). Environ. Sci. Technol.

Triebskorn, R., Braunbeck, T., Grummt, T., Hanslik, L., Huppertsberg, S., Jekel, M., Knepper, T.P., Krais, S., Müller, Y.K., Pittroff, M., Ruhl, A.S., Schmieg, H., Schür, C., Strobel, C., Wagner, M., Zumbülte, N., Köhler, H.-R., 2019. Relevance of nano- and microplastics for freshwater ecosystems: a critical review. Trends Anal. Chem. 110, 375-392.

Triebskorn, R., Schrerer, U., Braunbeck, T., 2019. Effektstudien in der Risikobewertung: Das Projekt Effect-Net und Ergebnisse des Workshops „Von der biologischen Wirkung zur Regulierung: Wie können neue Ansätze in der Stoffbewertung helfen?“ am 11. und 12. März 2019 in Tübingen. KW Korrespondenz Wasserwirtschaft 12-07, 1-5.

Zindler, F., Beedgen, F., Braunbeck, T., 2019. Time-course of coiling activity in zebrafish (Danio rerio) embryos exposed to ethanol as an endpoint for developmental neurotoxicity (DNT) - Hidden potential and underestimated challenges. Chemosphere 235, 12-20.

Zindler, F., Beedgen, F., Brandt, D., Steiner, M., Stengel, D., Baumann, L., Braunbeck, T., 2019. Analysis of tail coiling activity of zebrafish (Danio rerio) embryos allows for the differentiation of neurotoxicants with different modes of action. Ecotox. Environ. Safety 186, 109754.

Batel, A., Borchert, F., Reinwald, H., Erdinger, L., Braunbeck, T., 2018. Microplastic accumulation patterns and transfer of benzo[a]pyrene to adult zebrafish (Danio rerio) gills and zebrafish embryos. Environ. Poll. 235: 918-930.

Böhler, S., Lörracher, A.-K., Schubert, J., Braunbeck, T. (2018) Comparative live-imaging of in vivo EROD (ethoxyresorufin-O-deethylase) induction in zebrafish (Danio rerio) and fathead minnow (Pimephales promelas) embryos after exposure to PAHs and river sediment extracts. Sci. Total Environ. 621: 827-838.

Grummt, T., Braunbeck, T., Hollert, H., Kramer, M. (2018) Leitfaden − Gefährdungsbasiertes Risikomanagement für anthropogene Spurenstoffe zur Sicherung der Trinkwasserversorgung (Tox Box). Umweltbundesamt Bad Elster.

Grummt, T., Braunbeck, T., Hollert, H., Kramer, M. (2018) Leitfaden Gefährdungsbasiertes Risikomanagement für anthropogene Spurenstoffe zur Sicherung der Trinkwasserversorgung (Tox Box). BMBF-Fördermaßnahme „Risikomanagement von neuen Schadstoffen und Krankheitserregern im Wasserkreislauf“ RiSKWa.

Grummt, T., Seiler, T.-B., Braunbeck, T., Hollert, H. (2018) Effect-related evaluation of anthropogenic trace substances − concepts for genotoxicity, neurotoxicity and endocrine effects. Environ. Sci. Eur. 25: 3945-3950.

Heinrich, P., Braunbeck, T. (2018) Genetically engineered zebrafish liver (ZF-L) cells as an in vitro source for zebrafish acetylcholinesterase (zfAChE) for the use in AChE inhibition assays. Toxicol. in Vitro 52, 52-59.

Heinrich, P., Braunbeck, T. (2018) Microplastic testing in vitro: Realistic loading of pollutants, surfactant-free solid surface-dosing and bioanalytical detection using a sensitivity-optimized EROD assay. Toxicol. in Vitro 54, 194-201.

Kais, B., Ottermanns, R., Scheller, F., Braunbeck, T. (2018) Modification and quantification of in vivo EROD live-imaging with zebrafish (Danio rerio) embryos to detect both induction and inhibition of CYP1A. Sci. Tot. Environ. 615: 330-347.

Norberg-King, T.J., Embry, M.R., Belanger, S.E., Braunbeck, T., Butler, J.D., Dorn, P.B., Farr, B., Guiney, P.D., Hughes, S.A., Jeffries, M., Journel, R., Lèonard, M., McMaster, M., Oris, J.T., Ryder, K., Segner, H., Senac, T., Van Der Kraak, G., Whale, G., Wilson, P., 2018. An international perspective on the tools and concepts for effluent toxicity assessments in the context of animal alternatives: reduction in vertebrate use. Environ. Toxicol. Chem. 37, 2745-2757.

Rehberger, K., Baumann, L., Hecker, M., Braunbeck, T., 2018. Intrafollicular thyroid hormone staining in whole-mount zebrafish (Danio rerio) embryos for the detection of thyroid hormone synthesis disruption. Fish Physiol. Biochem. 44, 997-1010.

Stengel, D., Wahby, S., Braunbeck, T. (2018) In search of a comprehensible set of endpoints for the routine monitoring of neurotoxicity in vertebrates: sensory perception and nerve transmission in zebrafish (Danio rerio) embryos. Environ. Sci. Pollut. Res. 25: 4066-4084.

Zhao, H., Di Mauro, G., Lungu-Mitea, S., Negrini, P., Guarino, A.M., Frigato, E., Braunbeck, T., Ma, H., Lamparter, T., Vallone, D., Bertolucci, C., Foulkes, N.S., 2018. Modulation of DNA repair systems in blind cavefish during evolution in constant darkness. Curr. Biol. 28, 3229-3243.

Böhler, S., Strecker, R., Heinrich, P., Prochazka, E., Northcott, G.L., Ataria, J.A., Leusch, F.D.L., Braunbeck, T. Tremblay, L.A. (2017) Assessment of the toxicity of sediments of urban streams entering estuaries using multiple bioassays and chemical analysis. Sci. Total Environ. 593–594: 498–507.

Braunbeck, T., Grummt, T., Hollert, H. (2017) Leitfaden RiSKWa – die Bewertung anthropogener Spurenstoffe im Wasserkreislauf. Schriftenr. WaBoLu 159.

Eckhardt, A., Grummt, T., Kramer, M., Braunbeck, T., Hollert, H. (2017) ToxBox - a new approach for evaluating anthropogenic trace substances in drinking water. Naunyn-Schmiedeberg's Arch. Pharmacol. 390 (Suppl. 1): S1-S101.<

Grummt, T., Triebskorn, R., Oehlmann, J., Braunbeck, T., Happel, O. (2017) RiSKWa-Statuspapier: Methoden zur (öko-)toxikologischen Bewertung von Spurenstoffen im Wasserkreislauf – Ergebnisse des Querschnittsthemas „(Öko-)Toxikologie. DECHEMA/BMBF, 36 pp.

Grummt, T., Triebskorn, R., Oehlmann, J., Braunbeck, T., Happel, O. (2017) RiSKWa-Statuspapier: Methoden zur (öko-)toxikologischen Bewertung von Spurenstoffen im Wasserkreislauf – Ergebnisse des Querschnittsthemas „(Öko-)Toxikologie. DECHEMA/BMBF, 36 pp.

Heinrich, P., Petschick, L.L., Northcott, G.L., Tremblay, L.A., Ataria, J.A., Braunbeck, T. (2017) Assessment of cytotoxicity, genotoxicity and 7-ethoxyresorufin-O-deethylase (EROD) induction in sediment extracts from New Zealand urban estuaries. Ecotoxicology, 26: 211–226.

Kais, B., Schiwy, S., Hollert, H., Keiter, S.H., Braunbeck, T. (2017) In vivo EROD assays with the zebrafish (Danio rerio) as rapid screening tools for the detection of dioxin-like activity. Sci. Total Environ. 590-591:269-280.

Leist, M., Ghallab, A., Graepel, R., Marchan, R., Hassan, R., Bennekou, S.H., Limonciel, A., Vinken, M., Schildknecht, S., Waldmann, T., Danen, E., van Ravenzwaay, B., Kamp, H., Gardner, I., Godoy, P., Bois, F.Y., Braeuning, A., Reif, R., Oesch, F., Drasdo, D., Höhme, S., Schwarz, M., Hartung, T., Braunbeck, T., Beltman, J., Vrieling, H., Sanz, F., Forsby, A., Gadaleta, D., Fisher, C., Kelm, J., Fluri, D., Ecker, G., Zdrazil, B., Terron, A., Jennings, P., van der Burg, B., Dooley, S., Meijer, A.H., Willighagen, E., Martens, M., Evelo, C., Mombelli, E., Taboureau, O., Mantovani, A., Hardy, B., Koch, B., Escher, S., van Thriel, C., Cadenas, C., Kroese, D., van de Water, B., Hengstler, J.G. (2017) Adverse outcome pathways: opportunities, limitations and open questions. Arch. Toxicol. 91: 3477-3505.

Pelka, K.E., Henn, K., Keck, A. Sapel, B., Braunbeck, T. (2017) Size does matter – determination of the critical molecular size for the uptake of chemicals across the chorion of zebrafish (Danio rerio) embryos. Aquat. Toxicol. 185: 1-10.

Schmidt, F., Wolf, R., Baumann, L., Braunbeck, T. (2017) Ultrastructural alterations in thyrocytes of zebrafish (Danio rerio) after exposure to propylthiouracil and perchlorate. Toxicol. Pathol. 45: 649-662.

Stengel, D., Zindler, F., Braunbeck, T. (2017) An optimized method to assess ototoxic effects in the lateral line of zebrafish (Danio rerio) embryos. Comp. Biochem. Physiol. C Toxicol. Pharmacol.

Stengel, D., Zindler, F., Braunbeck, T. (2017) An optimized method to assess ototoxic effects in the lateral line of zebrafish (Danio rerio) embryos. Comp. Biochem. Physiol. C Toxicol. Pharmacol.

Ebke, K.P., Ahlers, J., Braunbeck, T., Oehlmann, J., Ratte, T., Schäfer, R.B., Eisenträger, A. and Schäffer, A. (2016) The German postgraduate degree program in ecotoxicology (SETAC GLB and GDCh): a success story. Environ. Sci. Eur. 28: 19.

Batel, A., Linti, F., Scherer, M., Erdinger, L., Braunbeck, T. (2016) Transfer of benzo[a]pyrene from microplastics to Artemia nauplii and further to zebrafish via a trophic food web experiment – CYP1A induction and visual tracking pf persistent organic pollutants. Environ. Toxicol. Chem. 35: 1656-1666.

Keiter, S., Burkhardt-Medicke, K., Wellner, P., Kais, B., Färber, H., Skutlarek, D., Engwall, M., Braunbeck, T., Keiter, S.H., Luckenbach, T. (2016) Does perfluorooctane sulfonate (PFOS) act as chemosensitizer in zebrafish embryos? Sci. Total Environ. 548-549: 317-324.

Klein, R., Gercken, J., Löffler, H., von der Trenck, T., Braunbeck, T. (2016) A novel German guideline for the sampling procedures for passive biomonitoring with fish as accumulation indicators: VDI 4230, Part 4. Environ. Sci. Eur. 28:15

Baumann, L., Knörr, S., Keiter, S., Nagel, T., Segner, H., Braunbeck, T. (2015) Prochloraz causes irreversible masculinization of zebrafish (Danio rerio). Environ. Sci. Pollut. Res. DOI 10.1007/s11356-014-3486-3.

Braunbeck, T. (2015) Wir müssen bis zu Ende denken. Umwelt direkt 1/2015, 8 – 9.

Braunbeck, T., Kais, B., Lammer, E., Otte, J., Schneider, K., Stengel, D., Strecker, R.T. (2015) The fish embryo test (FET): origin, applications, and future. Environ. Sci. Pollut. Res. 22: 16247–16261<

Kais, B., Stengel, D., Batel, A., Braunbeck, T. (2015) Acetylcholinesterase in zebrafish embryos as a tool to identify neurotoxic effects in sediments. Environ. Sci. Pollut. Res. 22: 16329–16339.

Kais, B., Stengel, D., Batel, A., Braunbeck, T. (2015) Erratum to: Acetylcholinesterase in zebrafish embryos as a tool to identify neurotoxic effects in sediments. Environ. Sci. Pollut. Res. 22: 16340

Schulze, T., Ulrich, M., Maier, D., Maier, M., Terytze, K., Braunbeck, T. and Hollert, H. (2015) Evaluation of the hazard potentials of river suspended particulate matter and floodplain soils in the Rhine basin using chemical analysis and in vitro bioassays. Environ. Sci. Pollut. Res. 22: 14606–14620.

Suares-Rocha, P., Braunbeck, T., de Francheschi de Angelis, D., Marin-Morales, M.A. (2015) Assessment of cytotoxicity and AhR-mediated toxicity in tropical fresh water sediments under the influence of an oil refinery. Environ. Sci. Pollut. Res. 22: 12566-12575.

Baumann, L., Knörr, S., Keiter, S., Rehberger, K., Volz, S., Schiller, V., Fenske, M., Holbech, H., Segner, H., Braunbeck, T. (2014) Reversibility of endocrine disruption in zebrafish (Danio rerio) after discontinued exposure to the estrogen 17α-ethinylestradiol. Toxicol. Appl. Phamracol. http://dx.doi.org/10.1016/j.taap.2014.04.025.

Busquet, F., Strecker, R., Rawlings, J.M., Belanger, S.E., Braunbeck, T., Carr, G.J., Cenijn, P., Fochtman, P., Gourmelon, A., Hübler, N., Kleensang, A., Knöbel, M., Kussatz, C., Legler, J., Lillicrap, A., Martínez-Jerónimo, F., Polleichtner, C., Rzodeczko, H., Salinas, E., Schneider, K.E., Scholz, S., van den Brandhof, E.-J., van der Ven, L.T.M., Walter-Rohde, S., Weigt, S., Witters, H. and Halder, M. (2014) OECD validation study to assess intra- and inter-laboratory reproducibility of the zebrafish embryo toxicity test for acute aquatic toxicity testing. Reg. Tox. Pharm. http://dx.doi.org/10.1016/j.yrtph.2014.05.018

Heinrich, P., Diehl, U., Förster, F. and Braunbeck, T. (2014) Improving the in vitro ethoxyresorufin-O-deethylase (EROD) assay with RTL-W1 by metabolic normalization and use of β-aphthoflavone as the reference substance. Comp. Biochem. Phys. 164C: 27-34. http://dx.doi.org/10.1016/j.cbpc.2014.04.005

Seiler, T.B., Best, N., Møller Fernqvist, M., Hercht, H., Smith, K.E.C., Braunbeck, T., Mayer, P. and Hollert, H. (2014) PAH toxicity at aqueous solubility in the fish embryo test with Danio rerio using passive dosing. Chemosphere 112: 77-84.

Seybold, B., Braunbeck, T. and Randler, C. (2014) Primate conservation − an evaluation of two different educational programs in Germany. Int. J. Sci. Math. Educ. 12: 285-305.

Baumann, L., Knörr, S., Keiter, S., Nagel, T., Rehberger,K., Volz, S., Oberrauch, S., Schiller, V., Fenske, M., Holbech, H., Segner, H., Braunbeck, T. (2014) Persistence of endocrine disruption in zebrafish (Danio rerio) after discontinued exposure to the androgen 17ß-trenbolone. Environ. Toxicol. Chem. 33:2488-2496

Baumann, L., Knörr, S., Keiter, S., Nagel, T., Segner, H., Braunbeck, T. (2014a) Prochloraz causes irreversible masculinization of zebrafish (Danio rerio). Environ. Sci. Pollut. Res. DOI 10.1007/s11356-014-3486-3

Scholz, S., Sela, E., Blaha, L., Braunbeck, T., Galay-Burgos, M., García-Franco, M., Guinea, J., Klüver, N., Schirmer, K., Tanneberger, K., Tobor-Kaplon, M., Witters, H., Belanger, S., Benfenati, E., Creton, S., Cronin, M.T.D., Eggen, R.I.L., Embry, M., Ekman, D., Gourmelon, A., Halder, M., Hardy, B., Hartung, T., Hubesch, B., Jungmann, D., Lampi, M.A., Lee, L., Marc Léonard, M., Küster, E., Lillicrap, A., Luckenbach, T., Murk, A.J., Navas, J.M., Peijnenburg, W., Repetto, G., Salinas, E., Schüürmann, G., Spielmann, H., Tollefsen, K.E., Walter-Rohde, S., Whale, G., Wheeler, J.R., Winter, M.J. (2013) A European perspective on alternatives to animal testing for environmental hazard identification and risk assessment. Regul. Toxicol. Parmacol. 67: 506-530.

Otte, J.C., Keiter, S., Faßbender, F., Higley, E.B., Suares Rocha, P., Brinkmann, M., Wahrendorf, D.-S., Manz, W., Wetzel, M.A., Braunbeck, T., Giesy, J.-P., Hecker, M., Hollert, H. (2013) Contribution of priority PAHs and POPs to Ah receptor-mediated activities in sediment samples from the River Elbe Estuary, Germany. PLoS ONE 8(10): e75596.

Kais. B., Schneider, K.E., Keiter, S., Henn, K., Ackermann, C., Braunbeck, T. (2013) DMSO modifies the permeability of the zebrafish (Danio rerio) chorion – implications for the fish embryo test (FET). Aquat. Toxicol. 140-141: 229-238.

Braunbeck, T., Walter-Rohde, S. (2013) Fish Embryo Acute Toxicity Test with Zebrafish (ZFET). ECVAM DB-ALM, http://ecvam-dbalm.jrc.ec.europa.eu

Baumann, L., Holbech, H., Keiter, S., Lund Kinnberg, K., Knörr, S., Nagel., T. Braunbeck, T. (2013) The maturity index as a tool to facilitate the interpretation of changes in vitellogenin production and sex ratio in the Fish Sexual Development Test. Aquat. Toxicol. 128-129: 34-42.

Faßbender, C., Braunbeck, T. (2013a) Assessment of genotoxicity in gonads, liver and gills of zebrafish (Danio rerio) by use of the comet assay and micronucleus test after in vivo exposure to methyl methanesulfonate. Bull. Environ. Contam. Toxicol. 91: 89-95.

Faßbender, C., Braunbeck, T. (2013b) Reproductive and genotoxic effects in zebrafish after chronic exposure to methyl methanesulfonate in a multigeneration study. Ecotoxicology  DOI 10.1007/s10646-013-1057-x.

Strecker, R., Weigt, S., Braunbeck, T. (2013) Cartilage and bone malformations in the head of zebrafish (Danio rerio) embryos following exposure to disulfiram and acetic acid hydrazide. Toxicol. Appl. Pharmacol. 268: 221-231.

Faßbender, C., Braunbeck, T., Keiter, S. (2012) Gene-TEQ – a standardized comparative assessment of effects in the comet assay using genotoxicity equivalents. J. Env. Monitor. 14: 1325-1334.177.    

Halder, M., Busquet, F., Amcoff, P., Gourmelon, A., Braunbeck, T., Belanger, S., Carr, G.J., Lillicrap, A. and Walter-Rohde, S. (2012) Validation report (phase 2) for the zebrafish embryo toxicity test. OECD Series on Testing and Assessment No. 179: 57 pp.

Halder, M., Busquet, F., Amcoff, P., Gourmelon, A., Braunbeck, T., Belanger, S., Carr, G.J., Lillicrap, A. and Walter-Rohde, S. (2012) Annexes to the validation report (phase 2) for the zebrafish embryo toxicity test. OECD Series on Testing and Assessment No. 179: 362 pp

Holbech, H., Kinnberg, K.L., Brande-Lavridsen, N., Bjerregaard, P., Petersen, G.I., Norrgren, L., Orn, S., Braunbeck, T., Baumann, L., Bomke, C., Dorgerloh, M., Bruns, E., Ruehl-Fehlert, C., Green, J.W., Springer, T.A., Gourmelon, A.  (2012) Comparison of zebrafish (Danio rerio) and fathead minnow (Pimephales promelas) as test species in the Fish Sexual Development Test (FSDT). Comp. Biochem. Physiol. 155 C: 407-415.

Keiter, S., Baumann, L., Färber, H., Holbech, H., Skutlarek, D., Engwall, M., Braunbeck, T. (2012) Long-term effects of a binary mixture of perfluorooctane sulfonate (PFOS) and bisphenol A (BPA) in zebrafish (Danio rerio). Aquat. Toxicol. 118-119: 116-129.

Kosmehl, T., Otte, J.E., Yang, L., Legradi, J., Bluhm, K., Zinsmeister, K., Keiter, S.H., Reifferscheid,  G., Manz, W., Braunbeck, T., Strähle, U., Hollert, H. (2012) A combined DNA-microarray and mechanism-specific toxicity approach with zebrafish embryos to investigate the pollution of river sediments. Reprod. Toxicol. 33: 254-253.

Peddinghaus, S., Brinkmann, M., Bluhm, K., Sagner, A., Hinger, G., Braunbeck, T., Eisenträger, A., Tiehm, A., Hollert, H., Keiter, S.H. (2012) Quantitative assessment of the embryotoxic potential of NSO-heterocyclic compounds using zebrafish (Danio rerio). Reprod. Toxicol. 33: 224-232.

Schmidt, F., Schnurr, S., Wolf, R., Braunbeck, T. (2012) Effects of the anti-thyroidal compound potassium-perchlorate on the thyroid system of the zebrafish. Aquat. Toxicol. 109: 47-58.

Schulze, T., Seiler, T.-B., Streck, G., Braunbeck, T., Hollert, H. (2012) Comparison of different exhaustive and biomimetic extraction techniques for chemical and biological analysis of polycyclic aromatic compounds in river sediments. J. Soils Sed. 12: 1419-1434.

Boettcher, M., Kosmehl, T., Braunbeck, T. (2011) Low-dose effects and biphasic effect profiles: is trenbolone a genotoxicant? Mutat. Res. 723: 152-157.

Grund, S., Higley, E., Schönenberger, R., Suter, M.J.F., Giesy, J.P., Braunbeck, T., Hecker, M., Hollert, H. (2011) The endocrine disrupting potential of sediments from the Upper Danube River (Germany) as revealed by in vitro bioassays and chemical analysis. Environ. Sci. Pollut. Res. 18: 446-460.

Henn, K., Braunbeck, T. (2011) Dechorionation as a tool to improve the fish embryo toxicity test (FET) with the zebrafish (Danio rerio). Comp. Biochem. Physiol. 153C: 91-98.

Hinger, G., Brinkmann, M., Bluhm, K., Sagner, A., Takner, H., Eisenträger, A., Braunbeck, T., Engwall, M., Tiehm, A., Hollert, H. (2011) Some heterocyclic aromatic compounds are Ah receptor agonists in the DR-CALUX assay and the EROD assay with RTL-W1 cells. Environ. Sci. Pollut. Res. 18: 1297-1304.

Osterauer, M., Faßbender, C., Braunbeck, T., Köhler, H.-R. (2011) Genotoxicity of platinum in embryos of zebrafish (Danio rerio) and ramshorn snail (Marisa cornuarietis). Sci. Toital Environ. 409: 2114-2119.

Rocha, P.S., Bernecker, C., Strecker, R., Mariani, C.F., Pompêo, M.L., Storch, V., Hollert, H., Braunbeck, T. (2011) Sediment-contact fish embryo toxicity assay with Danio rerio to assess particle-bound pollutants in the Tietê River Basin (São Paulo, Brazil). Ecotox. Environ. Safety 74: 1951-1959.

Schmidt, F., Braunbeck, T. (2011) Alterations along the hypothalamic-pituitary-thyroid axis of the zebrafish (Danio rerio) after exposure to propylthiouracil. J. Thyroid Res. doi:10.4061/2011/376243.

Schmidt, F., Schnurr, S., Wolf, R., Braunbeck T. (2011) Effects of the anti-thyroidal compound potassium-perchlorate on the thyroid system of the zebrafish. Aquat. Toxicol. 109C: 47-58.

Schweizer, N., Kummer, U., Hercht, H., Braunbeck T. (2011) Amplitude-encoded calcium oscillations in fish cells. Biophys Chem. 159: 294-302.

Strähle, U., Scholz, S., Geisler, R., Greiner, P., Hollert, H., Rastegar, S., Schumacher, A., Selderslaghs, I., Weiss, C., Witters, H., Braunbeck, T. (2011) Zebrafish embryos as an alternative to animal experiments. – A commentary on the definition of the onset of protected life stages in animal welfare regulations. Reprod Toxicol. 33: 128-132.

Strecker, R., Seiler, T.-B., Hollert, H., Braunbeck, T. (2011) Oxygen requirements of zebrafish (Danio rerio) embryos in embryo toxicity tests. Comp. Biochem. Physiol. 153C: 318-327.

Weigt, S., Huebler, N., Strecker, R., Braunbeck, T., Broschard, T.H. (2011a) Zebrafish (Danio rerio) embryos as a model for testing proteratogens. Toxicology 281: 25-36.

Weigt, S., Huebler, N., Strecker, R., Braunbeck, T., Broschard, T.H. (2011b) Developmental effects of coumarin and the anticoagulant coumarin derivative warfarin on zebrafish (Danio rerio) embryos. Reprod. Toxicol. 33: 133-141

Wetterauer, B., Ricking, M., Otte, J.C., Hallare, A.V., Rastall, A., Erdinger, L., Schwarzbauer, J., Braunbeck, T., Hollert, H. (2011) Toxicity, dioxin-like activities, and endocrine effects of DDT metabolites-DDA, DDMU, DDMS, and DDCN. Environ. Sci. Pollut. Res. 19: 403-415.

Wölz, J., Grosshans, K., Streck, G., Schulze, T., Rastall, A., Erdinger, L., Brack, W., Fleig, M., Kühlers, D., Braunbeck, T., Hollert, H. (2011) Estrogen receptor mediated activity in bankside groundwater, with flood suspended particulate matter and floodplain soil - an approach combining tracer substance, bioassay and target analysis. Chemosphere 85: 717-723.

Zielke, H., Seiler, T.-B., Niebergall, S., Leist, E., Brinkmann, M., Spira, D. Streck, G., Brack, W., Feiler, U., Braunbeck, T., Hollert, H. (2011) The impact of extraction methodologies on the toxicity of sediments in the zebrafish (Danio rerio) embryo test. J. Soils Sed. 11: 352-363.

Boettcher, M., Grund, S., Keiter, S., Kosmehl, T., Reifferscheid, G., Seitz, N., Rocha, P.S., Hollert, H., Braunbeck, T. (2010) Comparison of in vitro and in situ genotoxicity in the Danube River by means of the comet assay and the micronucleus test. Mutat. Res. 17: 11-17. [e-mail]

Braunbeck, T., Johnson, R., Wolf, J. (2010) Guidance document on the diagnosis of endocrine-related histopathology in fish gonads. Series on Testing and Assessment No. 123, 114 pp. [e-mail]

Embry, M.R., Belanger, S.E., Braunbeck, T., Galay-Burgos, M., Halder, M., Hinton, D.E., Léonard, M.A., Lillicrap, A., Norberg-King, T., Whale, G. (2010) The fish embryo toxicity test as an animal alternative method in hazard and risk assessment and scientific research. Aquat. Toxicol. 97: 79 - 87. [e-mail]

Grund, G., Keiter, S., Böttcher, M., Seitz, N., Wurm, K., Manz, W., Hollert, H., Braunbeck, T. (2010) Assessment of fish health status in the Upper Danube River by investigation of ultrastructural alterations in the liver of barbel Barbus barbus. Dis. Aquat. Org. 88: 235 - 248. [e-mail]

Halder, M., Léonard, M., Iguchi, T., Oris, J.T., Ryder, K., Belanger, S.E., Braunbeck, T., Embry, M.R., Whale, G., Norberg-King, T., Lillicrap, A. (2010) Regulatory aspects on the use of fish embryos in environmental toxicology. Integr. Environ. Assess. Man. 6: 484-491.

Keiter, S., Peddinghaus, S., Feiler, U., von der Goltz, B., Hafner, C., Ho, N.Y., Rastegar, S., Otte, J.CV., Ottermanns, R., Reifferscheid, G., Strähle, U., Braunbeck, T., Hammers-Wirtz, M., Hollert, H. (2010a) DanTox – ein BMBF-Verbundprojekt zur Ermittlung spezifischer Toxizität und molekularer Wirkungsmechanismen sedimentgebundener Umweltschadstoffe mit dem Zebrabärbling (Danio rerio). Umweltwiss. Schadst. Forsch. 22: 94 - 98. [e-mail]

Keiter, S., Peddinghaus, S., Feiler, U., von der Goltz, B., Hafner, C., Ho, N.Y., Rastegar, S., Otte, J.CV., Ottermanns, R., Reifferscheid, G., Strähle, U., Braunbeck, T., Hammers-Wirtz, M., Hollert, H. (2010b) DanTox—a novel joint research project using zebrafish (Danio rerio) to identify specific toxicity and molecular modes of action of sediment-bound pollutants. J. Soils Sediments 10: 714 - 717. [e-mail]

Knacker, T., Boettcher, M., Frische, T., Rufli, H., Stolzenberg, H.C., Teigeler, M., Zok, S., Braunbeck, T., Schäfers, C. (2010) Environmental effect assessment for sexual endocrine-disrupting chemicals: Fish testing strategy. Integr. Environ. Assess. Manag. 6: 653-662.

Otte, J., Schmidt, A., Hollert, H., Braunbeck, T. (2010) Spatio-temporal development of CYP1 activity in early life-stages of zebrafish (Danio rerio). Aquat. Toxicol. 100: 38-50. [e-mail]

Suares Rocha, P., Azab, E., Schmidt, B., Storch, V., Hollert, H., Braunbeck, T. (2010) Changes in toxicity and dioxin-like activity of sediments from the Tiete River (Sao Paulo, Brazil). Ecotoxicol. Environ. Safety 73: 550-558. [e-mail]

Ulrich, K., Wölfle, S., Mayer, A., Heeg, K., Braunbeck, T., Erdinger, L., Bartz, H. (2010) Extractable organic matter of standard reference material 1649a influences immunological response induced by pathogen-associated molecular patterns. Environ. Sci. Pollut. Res. 17: 1257-1267. [e-mail]

Weigt, S., Huebler, N., Braunbeck, T., von Landenberg, F., Broschard, T.H. (2010) Zebrafish teratogenicity test with metabolic activation (mDarT): Effects of phase I activation of acetaminophen on zebrafish Danio rerio embryos. Toxicology 275: 36-49. [e-mail]

Wolf, J., Johnson, R., Braunbeck, T. (2010) Guidance document on the diagnosis of endocrine-related histopathology in fish gonads. OECD Series on Testing and Assessment no. 123. OECD, Paris, ENV/JM/MONO(2010)14; 124 p.

Wölz, J., Brack, W., Moehlenkamp, C., Claus, E., Braunbeck, T., Hollert, H. (2010) Effect-directed analysis of Ah receptor-mediated activities caused by PAHs in suspended particulate matter sampled in flood events. Sci. Total Environ. 408: 3327 - 3333. [e-mail]

Wölz, J., Fleig, M., Schulze, T., Maletz, S., Lübcke von Varel, U., Reifferscheid, G., Kühlers, D., Braunbeck, T., Brack, W., Hollert, H. (2010) Impact of contaminants bound to suspended particulate matter in the context of flood events.  J. Soils Sed. 10: 1174-1185. [e-mail]

Wölz, J., Schulze, T., Lübcke-von Varel, U., Fleig, M., Reifferscheid, G., Brack, W., Kühlers, D., Braunbeck, T., Hollert, H. (2010) Investigation on soil contamination at recently inundated and non-inundated sites. J. Soils Sed. 11: 82-92.

Braunbeck, T. (2009) Zebrafish embryos as a model in general toxicology. Toxicol. Lett. 189S: 548-549. [e-mail]

Braunbeck, T., Hollert, H., Brauns, A., Keiter, S., Schwartz, P. (2009) Fischpopulationen unter Stress – das Beispiel des Unteren Neckars. UWSF – Umweltwiss. Schadst. Forsch. 21: 197-211. [e-mail]

Grim, K.C., Wolfe, M., Braunbeck, T., Iguchi, T., Ohta, Y., Tooi, O., Touart, L., Wolf, D.C., Tietge, J.  (2009) Thyroid histopathology assessments for the amphibian metamorphosis sssay to detect thyroid-active substances. Toxicol. Pathol. 37: 415-424. [e-mail]

Hollert, H., Ernst, M., Ahlf, W., Dürr, M., Erdinger, L., Grund, S., Keiter, S., Kosmehl, T., Seiler, T.-B., Wölz, J., Braunbedck, T. (2009a) Strategien zur Sedimentbewertung – ein Überblick. UWSF – Umweltwiss. Schadst. Forsch. 21: 160-176. [e-mail]

Hollert, H., Claus, C., Ahlf, W., Brack, W., Braunbeck, T., Hudjetz, S., Manz, W., Ratte, H.-T., Reifferscheid, G., Schäffer, A., Schulze, T., Schwarzbauer, J, Heininger, P. (2009b) Über die Notwendigkeit der wirkungsorientierten Analytik in einer umfassenden Wasserforschung. UWSF – Umweltwiss. Schadst. Forsch. 21:235-237. [e-mail]

Keiter, S., Böttcher, M., Grund, S., Seitz, N., Braunbeck, T., Hollert, H. (2009a) Der Fischrückgang in der oberen Donau. UWSF – Umweltwiss. Schadst. Forsch. 21:186-196. [e-mail]

Keiter, S., Braunbeck, T., Heise, S., Pudenz, S., Manz, W., Hollert, H. (2009b) A fuzzy logic-classification of sediments based on data from in vitro biotests. J. Soils Sed. 9: 168-179. [e-mail]

Lammer, E., Carr, G.J., Wendler, K., Rawlings, J.M., Belanger, S.E., Braunbeck, T. (2009a) Is the fish embryo toxicity test (FET) with the zebrafish (Danio rerio) a potential alternative for the fish acute toxicity test? Compo. Biochem. Physiol. 149C: 196-209.  [e-mail]

Lammer, E., Kamp, H.G., Hisgen, V., Koch, M., Reinhard, D., Salinas, E.R., Wendler, K., Zok, S., Braunbeck, T. (2009b) Development of a flow-through system for the fish embryo toxicity test (FET) with the zebrafish (Danio rerio). Toxicol. In Vitro 23: 1436-1442. [e-mail]

Opitz, R., Schmidt, F., Braunbeck, T., Wuertz, S., Kloas, W. (2009) Perchlorate and ethylenethiourea induce different histological and molecular alterations in a non-mammalian vertebrate model of thyroid goitrogenesis. Mol. Cell. Endocrinol. 298: 101 – 114. [e-mail]

Suares Rocha, P., Luvizotto, G.L., Kosmehl, T., Böttcher, M.  Storch, V., Braunbeck, T., Hollert, H. (2009) Sediment genotoxicity in the Tietê River(São Paulo, Brazil): In vitro comet assay versus in situ micronucleus assay studies. Ecotoxicol. Environ. Safety 72: 1842-1848.  [e-mail]

Weigt, S., Hubler, N., von Landenberg, F., Braunbeck, T., Broschard, T. (2009) Teratogenic effects of metabolically activated trimethadione in zebrafish (Danio rerio). Toxicol. Letters 189: S143. [e-mail]

Keiter, S., Grund, S., Bavel, B., Hagberg, J., Engwall, M., Kammann, U., Klempt. M., Manz, W., Olsman, H., Braunbeck, T., Hollert, H. (2008) Activities and identification of aryl hydrocarbon receptor agonists in sediments from the Danube river. Anal. Bioanal. Chem. 390: 2009-2019.  [e-mail]

Kosmehl, T., Hallare, A.V., Braunbeck, T., Hollert, H. (2008) DNA damage induced by genotoxicants in zebrafish (Danio rerio) embryos after contact exposure to freeze-dried sediment and sediment extracts from Laguna Lake (The Philippines) as measured by the comet assay. Mutat. Res. 650: 1-14.  [e-mail]

Pluskota, B., Storch, V., Braunbeck, T., Beck, M., Becker, N. (2008) First record of Stegomyia albopicta (Skuse) (Diptera: Culicidae) in Germany. Eur. Mosq. Bull. 26, 1-5. [e-mail]

Seitz, N., Boettcher, M., Keiter, S., Manz, W., Hollert, H., Braunbeck, T. (2008) A novel statistical approach for the evaluation of comet assay data. Mutat. Res. 652: 38-45. [e-mail]

Weigt, S., Busquet, F., von Landenberg, F., Braunbeck, T., Huebler, N., Broschard, T.H. (2008) Application of human and rat liver microsomes in teratogenicity testing using zebrafish Danio rerio embryos (mDarT). Toxicol. Letters 180: S96-S97. [e-mail]

Wölz, J., Engwall, M., Maletz, S., Olsman Takner, H., Bavel, B., Kammann, U., Klempt, M., Weber, R., Braunbeck, T., Hollert, H. (2008) Changes in toxicity and Ah receptor agonist activity of suspended particulate matter during flood events at the rivers Neckar and Rhine – a mass balance approach using in vitro methods and chemical analysis. Environ. Sci. Poll. Res. 15: 536-553. [e-mail]

Kosmehl, T., Krebs, F., Manz, W.,  Braunbeck, T., Hollert, H. (2007) Differentiation between bioavailable and total hazard potential of sediment-induced DNA fragmentation as measured by the comet assay with zebrafish embryos. J. Soils Sediments 7: 377-387. [e-mail]

Keiter, S, Rastall, A., Kosmehl, T., Wurm, K., Erdinger, L., Braunbeck, T., Hollert, H. (2006): Ecotoxico­logical assessment of sediment, suspended matter and water samples in the upper Danube river. A pilot study in search for the causes for the decline of fish catches, Environ. Science Poll. Res. 13: 308-319. [e-mail]

Kosmehl, T., Reifferscheid, G., Manz, W., Braunbeck, T., Hollert, H. (2006): A novel contact assay to assess genotoxic burden of sediments using the comet assay with zebrafish larvae. Environ. Toxicol. Chem. 25: 2097-2106. [e-mail]

Opitz, R., Hartmann, S., Blank, T., Braunbeck, T., Lutz, I., Kloas, W. (2006) Evaluation of histological and molecular endpoints for enhanced detection of thyroid system disruption in Xenopus laevis tadpoles. Toxicol. Sci. 90: 337-348. [e-mail]

Seiler, T.B.Rastall, A., Leist, E., Erdinger, L., Braunbeck, T., Hollert, H. (2006) Membrane dialysis extraction (MDE): a novel approach for extracting toxicologically relevant hydrophobic organic compounds from soils and sediments for assessment in biotests. J. Soils Sed. 6: 20-29. [e-mail]

Suares Rocha, P., Keiter, S., Luiz Martins Pompêo, M., Fioriollo Mariani, C., Lúcia Brandimarte, A., Seiler, T.-B., Kosmehl, T., Böttcher, B., Wölz, J., Braunbeck, T., Storch, V., Hollert, H. (2006) Weight-of-Evidence-Studie zur Sedimentbelastung des Tietê River in Brasilien. UWSF B Z Umweltchem Ökotox 18: 70. [e-mail]

Braunbeck, T., Böttcher, M., Hollert, H., Kosmehl, T., Lammer, E. Leist, E., Rudolf, R., Seitz, N. (2005) Towards an alternative for the acute fish LC₅₀ test in chemical assessment: the fish embryo toxicity test goes multi-species B an update. ALTEX 22: 87-102. [e-mail]

Hollert, H., Dürr, M., Holtey-Weber, R., Islinger, M., Brack, W., Färber, H., Erdinger, L., Braunbeck, T. (2005): Endocrine disruption of water and sediment extracts in a non-radioactive dot blot/RNAse protection-assay using isolated hepatocytes of rainbow trout - How explain deficiencies between bioanalytical effectiveness and chemically determined concentrations?  Environ. Science Poll. Res. 12: 347-360. [e-mail]

Opitz, R., Braunbeck, T., Bögi, C., Pickford, D.B., Nentwig, G., Oehlmann, J., Tooi, O., Lutz, I., Kloas, W. (2005) Description and initial evaluation of a Xenopus metamorphosis assay for detection of thyroid systemBdisrupting activities of environmental compounds. Environ. Toxicol. Chem. 24: 653-664. [e-mail]

Diekmann, M., Waldmann, P., Schnurstein, A., Grummt, T., Braunbeck, T., Nagel, R. (2004) On the relevance of genotoxicity for fish populations II: Genotoxic effects in zebrafish (Danio rerio) exposed to 4-nitroquinoline-1-oxide in a complete life-cycle test. Aquat. Toxicol. 68: 27-37. [e-mail]

Klee, N., Gustavsson, L., Kosmehl, T., Engwall, M., Erdinger, L. Braunbeck, T., Hollert, H. (2004) Changes in toxicity and genotoxicity of industrial sewage sludge samples containing nitro- and amino-aromatic compounds following treatment in bioreactors with different oxygen regimes. Environ. Sci. Pollut. Res. 11: 313-320. [e-mail]

Kosmehl, T., Krebs, F., Manz, W., Erdinger, L., Braunbeck, T., Hollert, H. (2004) Comparative genotoxicity testing of Rhine river sediment extracts using the comet assay with permanent fish cell lines (RTG-2 and RTL-W1) and the Ames test. J. Soils Sed. 4: 84-94. [e-mail]

Pawlowski, S.,  Jakob, S., Patzewitz, E.M. Annosova, I., Sauer, A. Leist, E., Braunbeck, T. (2004) Ein außergewöhnliches Habitat des Tyrrhenischen Laubfrosches Hyla sarda DE BETTA, 1857, am Monte Orlano, Elba, Italien. Sauria 26: 33-40. [e-mail]

Pawlowski, S., Sauer, A., Shears, J.A., Tyler, C.R., Braunbeck, T. (2004) Androgenic and estrogenic effects of the synthetic androgen 17α-methyltestosterone on sexual development and reproductive performance in the fathead minnow (Pimephales promelas) determined using the gonadal recrudescence assay. Aquat. Toxicol. 68: 277-291. [e-mail]

Pawlowski, S., Ternes, T.A., Bonerz, M., Rastall, A.C., Erdinger, L., Braunbeck, T. (2004) Estrogenicity of solid phase-extracted water samples from two municipal sewage treatment plant effluents and river Rhine water using the yeast estrogen screen. Toxicol. in vitro 18: 129-138. [e-mail]

Pawlowski, S., van Aerle, R., Tyler, C.R., Braunbeck, T. (2004) Effects of 17α-ethinylestradiol in a fathead minnow (Pimephales promelas) gonadal recrudescence assay. Ecotox. Environ. Safety 57: 330-345. [e-mail]

Braunbeck, T., Deventer, K., Eisenträger, A., Glück, U., Grummt, T., Gminski, R., Hansen, P.-D., Kramer, M., Mersch-Sundermann, V., Miltenburger, H.-G., Reifferscheid, G., Renberg, P., Schnurstein, A., Waldmann, P., Wittekindt, E., Zipperle, J. (2003) Gentoxizitätsprüfung im aquatischen Bereich B Möglichkeiten und Perspektiven. Vom Wasser 99: 137-232. [e-mail]

Castano,A., Bols, B., Braunbeck, T.,  Dierickx, P., Halder, M., Isomaa, B., Kawahara, K., Lee, L.E.J., Mothersill, C., Pärt, P., Repetto, G., Riego Sintes, J., Rufli, H., Smith, R., Wood, C., Segner, H. (2003) The use of fish cells in ecotoxicology B The report and recommendations of ECVAM workshop 47. ATLA 31: 317B351. [e-mail]

Hollert, H., Braunbeck, T.  (2003) Nachwuchsförderung in der Ökotoxikologie B New Blood in Ecotoxicology - UWSF B Z .Umweltchem. Ökotox .15: 281 B 282. [e-mail]

Hollert, H., Keiter, S., König, N., Rudolf, M., Ulrich, M., Braunbeck, T. (2003) A new sediment contact assay to assess particle-bound pollutants using zebrafish (Danio rerio) embryos. J. Soils  Sed. 3: 197-207. [e-mail]

Hollert, H., Haag, I., Dürr, M., Wetterauer, B., Holtey-Weber, R., Kern, U. Westrich, B., Färber, H., Erdinger, L., Braunbeck, T. (2003) Untersuchungen zum ökotoxikologischen Schädigungspoten­zial und Erosionsrisiko von kontaminierten Sedimenten in staugeregelten Flüssen. UWSF B Z. Umweltchem. Ökotox. 15: 5-12. [e-mail]

Islinger, M., Willimski, D., Völkl, A., Braunbeck, T. (2003) Effects of 17α-ethinylestradiol on the expression of three estrogen-regulated genes and cellular ultrastructure of liver and testes in male zebrafish. Aquat. Toxicol. 62: 85-103. [e-mail]

Pawlowski, S., Ternes, T., Bonerz, M., Kluczka, T., van der Burg, B., Nau, H., Erdinger, L., Braunbeck, T. (2003) Combined in situ and in vitro assessment of the estrogenic activity of sewage and surface water samples. Toxicol. Sci.75:57-65. [e-mail]

Schulze, T., Wetterauer, B., Schwarzbauer, J., Hollert, H.,  Braunbeck, T., Ricking, M. (2003) DDT und Metabolite in Sedimenten Berliner Gewässer: Vorkommen, Analytik und Schädigungspotential. UWSF B  Z. Umweltchem. Ökotox. 15: 71-77. [e-mail]

Segner, H., Braunbeck, T. (2003) End points for in vitro toxicity testing with fish cells. In: Mothersill, C., Austin, B. (eds.) In vitro methods in aquatic toxicology. Springer, Berlin, Heidelberg, pp. 77-142. [e-mail]

Triebskorn, R., Adam, S., Behrens, A., Beier, S., Böhmer, J., Braunbeck, T., Casper, H., Dietze, U., Gernhöfer, M., Honnen, W., Köhler, H.-R., Körner, W., Konradt, J., Lehmann, R., Luckenbach, T., Oberemm, A., Schwaiger, J., Segner, H., Strmac, M., Schüürmann, G., Siligato, S., Traunspurger, W. (2003) Establishing causality between pollution and effects at different levels of biological organization: the VALIMAR project. Human Ecol. Risk Assess. 9: 171-194. [e-mail]

Jobling, S., Casey, D., Rodgers-Gray, T., Oehlmann, J., Schulte-Oehlmann, U., Pawlowski, S., Braunbeck, T., Turner, A.P., Tyler, C.R. (2003) Comparative responses of molluscs and fish to environmental estrogens and an estrogenic effluent. Aquat. Toxicol. 65: 205-220. [e-mail]

Ahlf, W., Braunbeck, T., Heise, S. , Hollert, H.  (2002) Sediment and soil quality criteria. In: Burton, F., McKelvie, I., Förstner, U., Guenther, A. (2002; eds.): Environmental monitoring handbook. McGraw-Hill, New York, pp. 17-18. [e-mail]

Braunbeck, T., Segner, H., Meinelt, T. (2002) Toxicological aspects of modern aquaculture. Revue Méd. Vét. 153: 521-522. [e-mail]

Hollert, H., Dürr, M., Olsman, H., Halldin, K., Bavel, B.v., Brack, W., Tysklind, M., Engwall, M., Braunbeck, T. (2002) Biological and chemical determination of dioxin-like compounds in sediments by means of a sediment triad approach in the catchment area of the Neckar River. Ecotoxicology 11: 323-336. [e-mail]

Hollert, H., Heise, S., Pudenz, S., Brüggemann, R., Ahlf, W. and Braunbeck, T. (2002) Application of a sediment quality triad and different statistical approaches (hasse diagrams and fuzzy logic) for the comparative evaluation of small streams. Ecotoxicology 11: 311-321. [e-mail]

Islinger, M., Yuan, H., Völkl, A., Braunbeck, T. (2002) Measurement of vitellogenin gene expression by RT-PCR as a toll to identify endocrine disruption in Japanese medaka (Oryzias latipes). Biomarkers 7, 80-93. [e-mail]

Knörr, S., Braunbeck, T. (2002) Decline in reproduction success, sex reversal and developmental alterations in Japanese medaka (Oryzias latipes) after continuous exposure to octylphenol. Ecotox. Environ. Safety 51:187-196. [e-mail]

Schwaiger, J., Mallow, U., Ferling, H., Knoerr, S., Braunbeck, T., Kalbfus, W., Negele, R.D. (2002) How estrogenic is nonylphenol? A transgenerational study using rainbow trout (Oncorhynchus mykiss) as test organism. Aquat. Toxicol. 59: 177-189. [e-mail]

Strmac, M., Braunbeck, T. (2002) Cytological and biochemical effects of a mixture of 20 pollutants on isolated rainbow trout (Oncorhynchus mykiss) hepatocytes. Ecotox. Environ. Safety 53: 293-304. [e-mail]

Strmac, M., Oberemm, A., Braunbeck, T. (2002) Effects of sediment eluates and extracts from differently polluted small rivers on zebrafish embryos and larvae.  J. Fish Biol. 61: 24-38. [e-mail]

Ulrich, M., Schulze, T., Leist, E., Glaß, B., Maier, M., Maier, D., Braunbeck, T., Hollert, H. (2002) Ecotoxicological assessment of sediments and suspended particulate matter - potential risk of ground-water contamination and correlation of different exposure routes (organic extract, whole sediment) in the bacterial contact assay and the fish egg assay. UWSF B Z. Umweltchem. Ökotox. 14: 132-137. [e-mail]

Braunbeck, T., Segner, H. (2001) Isolation and cultivation of teleost hepatocytes. In: Berry, M., Edwards, A.M. (2001, eds.) The hepatocyte review. Kluwer Acad. Publ., Dordrecht, Boston, London, pp. 49-72. [e-mail]

Braunbeck, T., Strmac, M. (2001) Assessment of water and sediment contamination in small streams by means of cytological and biochemical alterations in isolated rainbow trout (Oncorhynchus mykiss) hepatocytes. J. Aquat. Ecosys. Stress Recov. 8: 337-354. [e-mail]

Dietze, U., Braunbeck, T., Honnen, W., Köhler, H.-R., Schwaiger, J., Segner, H., Triebskorn, R., Schüürmann, G. (2001) Chemometric discrimination between streams based on chemical, limnological and biological data taken from freshwater fishes and their interrelationships. J. Aquat. Ecosys. Stress Recov. 8 319-336. [e-mail]

Hinton, D.E., Segner, H., Braunbeck, T. (2001) Toxic responses of the liver. In: Schlenk, D., Benson, W.H. (2001; eds.) Target organ toxicity in marine and freshwater teleosts. Taylor & Francis, London & New York, pp. 224-268. [e-mail]

Konradt, J., Braunbeck, T. (2001) Alterations of selected metabolic enzymes in fish following long-term exposure to contaminated streams. J. Aquat. Ecosys. Stress Recov. 8 299-318. [e-mail]

Schnurstein, A., Braunbeck, T. (2001) Tail moment versus tail length - application of an in vitro version of the comet assay in biomonitoring for genotoxicity in native surface waters using primary hepatocytes and gill cells from zebrafish (Danio rerio). Ecotox. Environ. Safety 49: 187-196. [e-mail]

Triebskorn, R., Böhmer, J., Braunbeck, T., Honnen, W., Köhler, H.-R., Lehmann, R., Oberemm, A., Schwaiger, J., Segner, H., Schüürmann, G., Traunspurger, W. (2001) The project VALIMAR (VALIdation of bioMARkers for the assessment of small stream pollution): objectives, experimental design, summary of results, and recommendations for the application of biomarkers in risk assessment. J. Aquat. Ecosys. Stress Recov. 8: 161-178. [e-mail]

Braunbeck, T. (2000) Biotests with fish cell cultures - dreams and reality: Chances and limitations of alternatives to conventional toxicity tests with fish. In: Schöffl, H., Soielmann, H., Gruber, F.P., Appl, H., Harrer, F., Pfaller, W., Tritthart, H.A. (eds.) Forschung ohne Tierversuche 2000. Springer, Wien, New York, pp. 203-211. [e-mail]

Hollert, H., Dürr, M., Erdinger, L., Braunbeck, T. (2000) Cytotoxicity of settling particulate matter and sediments of the river Neckar (Germany) during a winter flood. Environ. Toxicol. Chem. 19: 528-534. [e-mail]

Pawlowski, S., Islinger, M., Völkl, A., Braunbeck, T. (2000) Temperature-dependent vitellogenin-mRNA expression in primary cultures of rainbow trout (Oncorhynchus mykiss) hepatocytes at 14 and 18 °C. Toxicol. in vitro 14: 531-540. [e-mail]

Strmac, M., Braunbeck, T. (2000) Isolated hepatocytes of rainbow trout (Oncorhynchus mykiss) as a tool to discriminate between differently contaminated small river systems.  Toxic. in Vitro 14: 361-377. [e-mail]

Braunbeck, T. (1999) Chances and limitations of in vitro methods with fish cell cultures for the assessment of the toxicity of aquatic pollutants. Verh. Ges. Ichthyol. 1: 1-14. [e-mail]

Bieberstein, U., Braunbeck, T. (1999) Immunohistochemical localization of vitellogenin in rainbow trout (Oncorhynchus mykiss) hepatocytes using immunofluorescence. Sci. Total Environ. 233, 67-75. [e-mail]

Berbner, T., Rahman, N., Braunbeck, T. (1999) Induction of cytochrome P450 1A and DNA damage in isolated rainbow trout (Oncorhynchus mykiss) hepatocytes by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Biomarkers 4: 214-228. [e-mail]

Braunbeck, T., Appelbaum, S. (1999) Ultrastructural alterations in the liver and intestine of carp (Cyprinus carpio) induced by ultra-low peroral doses of endosulfan. Dis. aquat. Org. 36: 183-200. [e-mail]

Burkhardt-Holm, P., Oulmi, Y., Schroeder, A, Braunbeck, T. (1999) Toxicity of 4-chloro­ani­line in early life-stages of zebrafish (Brachydanio rerio): II. Cytopathology of liver and gills after exposure to water-borne 4-chloroaniline. Arch. Environ. Contam. Toxicol. 37: 85-102. [e-mail]

Hollert, H., Dürr, M., Geier, V., Braunbeck, T. (1999) Ökotoxikologie in vitro: Gefährdungspoten­tial in Neckarsedimenten. In: Oehlmann, J., Markert, B. (eds.) Ökotoxikologie - Ökosystemare Ansätze und Methoden. Ecomed, Landsberg, pp. 444-462. [e-mail]

Islinger, M., Pawlowski, S., Hollert, H., Völkl, A., Braunbeck, T. (1999) Measurement of vitellogenin-mRNA expression in primary cultures of rainbow trout hepatocytes in a non-radioactive dot blot/RNAse protection-assay. Sci. Total. Environ. 233, 109-122. [e-mail]

Knörr, S., Bohl, M., Braunbeck, T. (1999) Die Entwicklung roter und weißer Muskulatur bei juvenilen Huchen (Hucho hucho) unter dem Einfluss unterschiedlicher Strömung S ein Beitrag zur Optimierung der Kondition zur Ausbürgerung in natürliche Habitate.  Verh. Ges. Ichthyol. 1: 109-127. [e-mail]

Strmac, M., Braunbeck, T. (1999) Effects of triphenyltin acetate on early life-stages of zebrafish (Danio rerio). Ecotox. Environ. Safety 44: 25-39. [e-mail]

Schramm, M., Behrens, A., Braunbeck, T., Eckwert, H., Köhler, H.-R., Konradt, J., Müller, E., Pawert, M., Schwaiger, J., Segner, H., Triebskorn, R. (1999) Cellular, histological and biochemical biomarkers. In: Gerhardt, A. (ed.) Biomonitoring of polluted water - reviews on actual topics. Environ. Science Forum 96; Trans Tech Publ., Uetikon-Zürich, pp. 33-64. [e-mail]

Triebskorn, R., Adam, S., Behrens, A., Braunbeck, T., Gränzer, S., Honnen, W., Konradt, J., Köhler, H.-R., Oberemm, A., Pawert, M., Schlegel, T., Schramm, M., Schüürmann, G., Schwaiger, J., Segner, H., Strmac, M., Müller, E. (1999) Eignung von Biomarkern zur Fließgewässerbewertung: Zwischenergebnisse aus dem Projekt `ValimarA (1995-1997). In: Oehlmann, J., Markert, B. (eds.) Ökotoxikologie - Ökosystemare Ansätze und Methoden. Ecomed, Landsberg, pp. 399-407. [e-mail]

Bieberstein, U., Braunbeck, T. (1998) Light and scanning electron microscopic cytopathology of 3,5-dichloro­phenol in the permanent fish cell line RTG-2. Ecotox. Environ. Safety 41: 298-306. [e-mail]

Braunbeck, T. (1998) Cytological alterations in fish hepatocytes following in vivo and in vitro sublethal exposure to xenobiotics – structural biomarkers of environmental contamination. In: Braunbeck, T., Hinton, D.E., Streit, B. (eds.) Fish ecotoxicology. Birkhäuser, Basel, pp. 61-140. [e-mail]

Feldhusen, F., Braunbeck, T., Wallner, F. (1999) Dysphagia after eating sea foods. Pyriform sinus foreign body with perforation and abscess of the parapharyngeal space. HNO 47: 746-747. [e-mail]

Hollert, H., Dürr, M., Erdinger, L., Braunbeck, T. (1998) Wie giftig sind Schadstoffe und Sedimente des Neckars? Zur Eignung von Biotests und Bioassay-dirigierten Fraktionierungstechniken für die Bewertung des Schadstoffpotentials in hydrologischen Fallstudien. J. Heidelberger Geograph. Ges. 13: 130-145. [e-mail]

Scholz, S., Braunbeck, T., Segner, T. (1998) Viability and differential function of rainbow trout hepatocytes in primary culture: the influence of culture conditions. In Vitro Cell. Dev. Biol. 34: 762-771. [e-mail]

Segner, H., Braunbeck, T. (1998) Cellular response profile to chemical stress. In: Schüürmann, G., Markert, B. (eds.) Ecotoxicology. Wiley, J. & Sons, Inc. and Spektrum Akademischer Verlag, pp. 521-569. [e-mail]

Braunbeck, T. (1997) Alternative methods in aquatic ecotoxicology. Eco-Informa 12:446-451. [e-mail]

Braunbeck, T., Hollert, H., Dürr, M., Erdinger, L.F. (1997) Biotests in der Ökotoxikologie am Beispiel des Fischzelltests. Veröff. PAÖ 22: 241-256. [e-mail]

Hofer, R., Köck, G., Braunbeck, T. (1997) Nuclear alterations in hepatocytes of Arctic char Salvelinus alpinus from acidic high alpine lakes. Dis. aquat. Org. 28: 139-150. [e-mail]

Moutou, K.A., Braunbeck, T., Houlihan, D.F. (1997) Quantitative analysis of alterations in liver ultrastructure of rainbow trout Oncorhynchus mykiss after administration of the aquaculture antibacterials oxolinic acid and flumequine. Dis. Aquat. Org. 29: 21-34.b [e-mail]

Zanger, M., Gräff, S., Braunbeck, T., Alberti, G., Köhler, H.-R. (1997) Detection and induction of cytochrome P450IA (CYP 1A)-like proteins in Julus scandinavius (Diplopoda) and Oniscus asellus (Isopoda): A first analysis. Bull. Environ. Contam. Toxicol. 58: 511-517. [e-mail]

Scholz, S., Behn, I., Honeck, H., Hauck, C., Braunbeck, T., Segner, H. (1997) Development of a monoclonal antibody for ELISA of CYP1A in primary cultures of rainbow trout (Oncorhynchus mykiss) hepatocytes. Biomarkers 2: 287-294. [e-mail]

Arnold, H., Pluta, H.-J., Braunbeck, T. (1996a) Cytological alterations in the liver of rainbow trout Oncorhynchus mykiss after prolonged exposure to low concentrations of waterborne endosulfan. Dis. aquat. Org. 25: 39-52. [e-mail]

Arnold, H., Pluta, H.-J., Braunbeck, T. (1996b) Sublethal effects of prolonged exposure to disulfoton in rainbow trout (Oncorhynchus mykiss): cytological alterations in the liver by a potent acetylcholine esterase inhibitor. Ecotox. Environ. Safety 34: 43-55. [e-mail]

Oulmi, Y, Braunbeck, T. (1996) Toxicity of 4-chloroaniline in early life-stages of zebrafish (Brachydanio rerio): I. Cytopathology of liver and kidney after microinjection. Arch. Environ. Contam. Toxicol. 30: 390-402. [e-mail]

Zahn, T., Arnold, H., Braunbeck, T. (1996) Cytological and biochemical response of R1 cells and isolated hepatocytes from rainbow trout (Oncorhynchus mykiss) to subacute in vitro exposure to disulfoton. Exp. Toxicol. Pathol. 48: 47-64. [e-mail]

Arnold, H., Pluta, H.-J., Braunbeck, T. (1995) Simultaneous exposure of fish to endosulfan and disulfoton in vivo: ultrastructural, stereological and biochemical reactions in hepatocytes of male rainbow trout (Oncorhynchus mykiss). Aquat. Toxicol. 33: 17-43. [e-mail]

Braunbeck, T., Berbner, T., Bieberstein, U., Erdinger, L., Geier, V., Hollert, H., Leist, E., Rahman, N., Zipperle, J.  (1995) Toxikologische und ökotoxikologische Untersuchung und Bewertung verschiedener Komparti­men­te in Fließgewässern mit Hilfe eines mehrstufigen Prüfsystems mit Zellkulturen aus Fischen. PAÖ 12: 345-358. [e-mail]

Braunbeck, T., Hauck, C., Scholz, S., Segner, H. (1995) Mixed function oxygenases in cultured fish cells: contributions of in vitro studies to the understanding of MFO induction. Z. angew. Zool. 81: 55-72. [e-mail]

Hollert, H., Dürr, M., Dörr, I., Erdinger, L.F., Zipperle, J., Braunbeck, T. (1996) Toxikologische und ökotoxikologische Untersuchung und Bewertung der Komparti­men­te in Fließgewässern mit Hilfe von Zellkulturen aus Fischen. Veröff. PAÖ 16: 469-488. [e-mail]

Oulmi, Y., Negele, R.-D., Braunbeck, T. (1995) Segment specificity of the cytological re­spon­se in rain­bow trout (Onco­rhynchus mykiss) renal tubules following prolonged exposure to sub­lethal con­cen­tra­tions of atrazine. Ecotox. Environ. Safety 32: 39-50. [e-mail]

Oulmi, Y., Negele, R.-D., Braunbeck, T. (1995) Cytopathology of liver and kidney in rain­bow trout Oncorhyn­chus mykiss after long-term exposure to sublethal concentra­tions of linuron. Dis. aquat. Org. 21: 35-52. [e-mail]

Zahn, T., Hauck, C., Holzschuh, J., Braunbeck, T. (1995) Acute and sublethal toxicity of seepage waters from garbage dumps to permanent cell lines and primary cultures of hepatocytes from rainbow trout (Oncorhynchus mykiss): a novel approach to environmental risk assessment for chemicals and chemical mixtures. Zbl. Hyg. 196: 455-479. [e-mail]

Zahn, T., Braunbeck, T. (1995) Cytotoxic effects of sublethal concentrations of malachite green in isolated hepatocytes from rainbow trout (Oncorhynchus mykiss). Toxic. in Vitro 9: 729-741. [e-mail]

Arnold, H., Braunbeck, T. (1994) Disulfoton as a major toxicant in the Rhine chemical spill at Basle in 1986: acute and chronic studies with eel and rainbow trout. In: Müller R, Lloyd R (eds.) Sublethal and chronic effects of pollutants on freshwater fish. Blackwell, Oxford, pp. 75-87. [e-mail]

Braunbeck, T. (1994a) Entwicklung von Biotestverfahren mit Zellkulturen aus Fischen zum Nachweis letaler und subletaler Schäden von Organismen durch Um­weltschadstoffe im Wasser. – Zelluläre Biomarker in Fischzellkulturen. PAÖ 8: 533-558. [e-mail]

Braunbeck, T. (1994b)  Detection of environmentally relevant concentrations of toxic organic compounds using histological and cytological parameters: substance-specificity in the reaction of rainbow trout liver? In: Müller, R., Lloyd, R. (eds.) Sublethal and chronic effects of pollutants on freshwater fish. Blackwell, Oxford, pp. 15-29. [e-mail]

Phromkunthong, W., Storch, V., Braunbeck, T. (1994) Sexual dimorphism in the reaction of zebrafish (Brachydanio rerio) to as­cor­bic acid defi­cien­cy: Induction of steatosis in hepatocytes of male fish. J. Appl. Ichthyol. 10: 146-153. [e-mail]

Schmidt, H., Ritter, G., Ruider, S., Schmahl, G., Mehlhorn, H., Braunbeck, T. (1994) Administra­tion of a medicated food containing malachite green for the control of ectoparasitic diseases of ornamental fish. Mem. Inst. Océano. P. Ricard, Leipzig 1994, 57-61. [e-mail]

Triebskorn, R., Köhler, H.-R., Flemming, J., Braunbeck,  T., Negele, R.D., Rahmann, H. (1994) Evaluation of bis(tri-n-butyltin)oxide (TBTO) neurotoxicity in rainbow trout (Oncorhynchus mykiss). I. Behaviour, weight increase, and tin content. Aquat. Toxicol. 30: 189-197 [e-mail]

Triebskorn, R., Köhler, H.R., Körtje, K.H., Negele, R.D., Rahmann, H., Braunbeck, T. (1994) Evaluation of bis(tri-n-butyltin)oxide (TBTO) neurotoxicity in rainbow trout (On­co­rhynchus mykiss). II. Ultrastructural diagnosis and tin localization by energy filtering transmission electron micros­copy (EFTEM). Aquat. Toxicol. 30: 199-213. [e-mail]

Braunbeck, T. (1993a) Cytological alterations in isolated hepatocytes from rainbow trout (Oncorhynchus mykiss) exposed in vitro to 4-chloroaniline. Aquat. Toxicol. 25: 83-110. [e-mail]

Braunbeck, T. (1993b) Entwicklung von Biotestverfahren mit Zellkulturen aus Fischen und Mollusken zum Nachweis letaler und subletaler Schäden von Organismen durch Umweltschadstoffe im Wasser. PAÖ 7: 537-559. [e-mail]

Braunbeck, T., Völkl, A. (1993) Toxicant-induced cytological alterations in fish liver as biomarkers of environmental pollution? A case study on hepatocellular effects of dinitro-o-cresol in golden ide (Leu­cis­cus idus melanotus). In: Braunbeck, T., Hanke, W., Segner, H. (eds.) Fish - Ecotoxicology and Ecophysiolo­gy, VCH, Weinheim, pp. 55-80. [e-mail]

Braunbeck, T., Hauck, C., Zahn, T. (1993) Primärzellkulturen aus Fischhepatocyten als alternatives Testsystem in der ökotoxikologischen Forschung. In: Hardegg, W., Livaditis, I., Vogt, M. (eds.) Tierschutz durch Alternativen. Verlag Gesundheit, Berlin, pp. 243-247. [e-mail]

Lester, S.M., Braunbeck, T., Teh, S.J., Stegeman, J.J., Miller, M.R., Hinton, D.E. (1993) Hepatic cellular distribution of cytochrome P-450 IA1 in rainbow trout (Oncorhynchus mykiss): an immunohisto- and cytochemical study. Cancer Res. 53, 3700-3706. [e-mail]

Zahn, T., Braunbeck, T. (1993) Isolated fish hepa­tocy­tes as a tool in aquatic toxicology: sublethal effects of dinitro-o-cresol and 2,4-dichloro­phenol. Sci. Total Environ. Suppl., pp. 721-734. [e-mail]

Zahn, T., Hauck, C., Braunbeck, T. (1993a) Fischfibrocyten als alternatives Testsystem: Untersuchung subletaler Effekte umweltrelevanter Schadstoffe mit R1-Zellen. In: Hardegg, W., Livaditis, I., Vogt, M. (eds.) Tierschutz durch Alternativen. Verlag Gesundheit, Berlin, pp. 301-306. [e-mail]

Zahn, T., Hauck, C., Braunbeck, T. (1993) Cytological altera­tions in fish fibrocytic R1 cells as an alternative test system for the detection of sublethal effects of environ­mental pollutants: a case-study with 4-chloroaniline. In: Braun­beck, T., Hanke, W., Segner, H. (eds.) Fish - Ecotoxico­logy and Ecophysiology, VCH, Weinheim, pp. 103-126. [e-mail]

Braunbeck, T. (1992) Isolierte Hepatocyten und Dauerzellinien aus Fischen im Cytotoxizitätstest – eine Alternative zur Fischleberzelle in vivo? In: Schöffl, H., Schulte-Hermann, R., Tritthart, H.A. (eds.) Möglichkeiten und Grenzen der Reduktion von Tierversuchen. Springer Verlag, Wien,  New York, pp. 153-154. [e-mail]

Braunbeck, T., Segner, H. (1992) Preexposure temperature acclimation and diet as mo­di­fy­ing fac­­tors for the tolerance of golden ide (Leuciscus idus melanotus) to short-term exposure to 4-chloroaniline. Ecotox. Environ. Safety 24: 72-94. [e-mail]

Braunbeck, T., Storch, V. (1992) Senescence of hepatocytes isolated from rainbow trout (Onco­rhyn­chus mykiss) in primary culture. An ultrastructural study. Protoplasma 170: 138-159. [e-mail]

Braunbeck, T., Burkhardt-Holm, P., Görge, G., Nagel, R., Negele, R.-D., Storch, V. (1992) Re­gen­bo­gen­forelle und Zebrabärbling, zwei Modelle für verlängerte Toxizitätstests: Relative Empfindlich­keit, Art- und Organspezifität in der cytopa­thologischen Reaktion von Leber und Darm auf Atra­zin. Schriftenr. Ver. Wasser Boden Lufthyg. 89: 109-145. [e-mail]

Braunbeck, T., Teh, S.J., Lester, S.M., Hinton, D.E. (1992) Ul­trastructural alterations in hepato­cytes in liver of medaka (Oryzias latipes) exposed to diethylnitros­amine. Toxicol. Pathol. 20: 179-196. [e-mail]

Lester, S.M., Braunbeck, T., Teh, S.J., Stegeman, J.J., Miller, M.R., Hinton, D.E. (1992) Immunocytochem­ical localization of cytochrome P 450 1A1 in liver of rainbow trout (Oncorhynch­us mykiss). Mar. Environ. Res. 34: 117-122. [e-mail]

Spazier, E., Storch, V., Braunbeck, T. (1992) Cytopathology of spleen in eel Anguilla an­guil­la exposed to a chemical spill in the Rhine river. Dis. aquat. Org. 14: 1-22. [e-mail]

Braunbeck, T., Völkl, A. (1991) Induction of biotransformation in the liver of eel (An­guil­la an­guil­la L.) by sublethal exposure to dinitro-o-cresol: An ul­trastructural and bio­chemical study. Ecotox. Environ. Safety 21: 109-127. [e-mail]

Braunbeck, T., Storch, V., Bresch, H. (1990) Species-specific reaction of li­ver ul­­trastruc­ture in zebra fish (Brachydanio rerio) and trout (Salmo gaird­neri) after pro­­longed exposure to 4-chloroaniline. Arch. Environ. Con­tam. Toxicol. 19: 405-418. [e-mail]

Braunbeck, T., Burkhardt-Holm, P., Storch, V. (1990) Liver pathology in eels (Anguilla an­guilla L.) from the Rhine river exposed to the chemical spill at Basle in November 1986. Limnologie  aktuell 1: 371-392. [e-mail]

Braunbeck, T., Görge, G., Storch, V., Nagel, R. (1990) Hepatic steatosis in zebra­ fish (Brachy­danio rerio) induced by long-term exposure to γ-hexachlorocyclo­hexane. Ecotox. Environ. Safety 19: 355-374. [e-mail]

Segner, H., Braunbeck, T. (1990a) Adaptive changes of liver composition and structure in golden ide during winter acclimatization. J. Exp. Zool. 255: 171-185. [e-mail]

Segner, H., Braunbeck, T. (1990b) Qualitative and quantitative assessment of the response of milk­fish, Chanos chanos, fry to low-level copper ex­po­sure. In: Perkins, F., Cheng, T.C. (eds.) Pa­tho­logy in Marine Science (Procee­dings of PAMAQ III, Gloucester Point, Virginia), pp. 347-368. [e-mail]

Segner, H., Braunbeck, T. (1990c) Qualitative and quantitative assessment of the response of milk­fish, Chanos chanos, fry to low-level copper ex­po­sure. In: Perkins, F.O., Cheng, T.C. (eds.) Pa­tho­logy in Marine Science (Proc. PAMAQ III, Gloucester Point, Virginia), pp. 347-368. [e-mail]

Burkhardt-Holm, P., Braunbeck, T., Storch, V. (1990) Aus­wir­kung der beim San­­doz-Un­fall im No­vember 1986 in den Rhein ge­langten Chemika­lien auf die Ultra­struktur des Darms von Aalen. Limnologie aktuell 1: 393-404. [e-mail]

Braunbeck, T., Nagel, R., Storch, V. (1989) Sex-specific reaction of liver ul­tra­structure in zebra fish (Brachydanio rerio) after prolonged sub­lethal exposure to 4-nitrophe­nol. Aquat. Toxicol. 14: 185-202. [e-mail]

Storch, V., Braunbeck, T., Waitkuwait, W.-E. (1989) The liver of the West Af­ri­­can cro­co­dile Osteolaemus tetraspis:An ultrastructural study. J. Submicr. Cytol. Pathol. 21: 317-327. [e-mail]

Braunbeck, T., Storch, V. (1989) Zelle und Umwelt: Wie wirken sich Um­welt­­­gif­te auf Zel­len aus? Biologie in unserer Zeit 89/4: 127-132.

Braunbeck, T., Bresch, H., Nagel, R. (1989) Stoffspezifische Reaktionen der Ultrastruktur der Le­­ber des Zebra­bärb­lings (Brachydanio rerio) auf Chemikalien. Verh. Dt. Zool. Ges. 82: 183.

Rafael, J., Braunbeck, T. (1988) Interacting effects of diet and environmental tempera­ture on bio­chem­ical para­meters in the liver of Leuciscus idus melanotus (Cy­pri­ni­dae: Teleostei). Fish Physiol. Biochem. 5: 9-19. [e-mail]

Segner, H., Braunbeck, T. (1988) Hepatocellular adaptation to extreme nu­tri­­tion­al cond­i­tions in ide, Leuciscus idus melanotus L. (Cypri­nidae). A mor­pho­functional analysis. Fish Physiol. Bio­chem. 5: 79-97. [e-mail]

Braunbeck, T., Dales, R.P. (1984) The role of the heart-body and of the ex­tra­vasal tissue in disposal of foreign cells in two polychaete annelids. Tissue & Cell 16: 557-563. [e-mail]

Braunbeck, T., Dales, R.P. (1985) The ultrastructure of the heart-body and ex­tra­vasal tissue in the poly­chaete annelids Neoamphitrite figulus and Arenicola marina. J. mar. biol. Ass. U.K. 65: 653-662. [e-mail]

Braunbeck, T. , Gorgas, K., Storch, V., Völkl, A. (1987) Ultrastructure of he­pa­to­cytes in golden ide (Leuciscus idus melanotus L.; Cyprinidae: Teleostei) during thermal adap­t­ation. Anat. Embryol. 175: 303-313. [e-mail]